Arecoline is a novel and potent agonist of muscarinic acetylcholine.
Corydaline is a bioactive and naturally occurring isoquinoline alkaloid extracted from Corydalis yanhusuo.
Decamethonium bromide (Syncurine; Decamethonum; Lopac-D-1260; (DM)Br2 Syncurine), a quaternary ammonium ion, is a short-acting, depolarizing muscle relaxant and/or neuromuscular blocker used in anesthesia to induce paralysis.
Gallamine Triethiodide (Flaxedil; Tricuran; Gallamoni jodidum; Gallaminii iodidum), a non-depolarising muscle relaxant, is a potent and cardioselective cholinergic receptor blocker with an IC50 of 68.0 ± 8.4 μM.
Tropicamide (formerly Ro-17683; Ro 1-7683; trade names Mydral; Mydriafair; Mydriaticum; Mydrum), an approved medication used to dilate the pupil and help with eye examination, is a potent anticholinergic and a muscarinic receptor isoform M4 antagonist with important biological activity. It inhibits M4-muscarinic receptor with an IC50 of 8.0 nM. It is short acting drug for […]
Varenicline Tartrate (CP-526555 18; CP 526555 18; Chantix; Champix), the tartrate salt of varenicline, is a potent partial agonist of nicotinic AChR (acetylcholine receptor) used for smoke-cessation and nicotine addiction.
Darifenacin HBr (formerly known as UK-88525; Emselex; Enablex), the hydrobromide salt of Darifenacin, is a approved medication used to treat urinary incontinence and overactive bladder.
Solifenacin succinate (formerly YM-905; YM905; Trade name: Vesikur; Vesicare), the succinate salt of solifenacin which is approved for treating overactive bladder, is a novel and potent muscarinic receptor antagonist with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively.
Tolterodine tartrate (PNU-200583E; PNU200583E; Detrol LA; Detrusitol) is a tartrate salt of tolterodine that is a potent and competitive muscarinic receptor antagonist.
Hexamethonium Bromide (Vegolysen; Esametina; Simpatoblock), a peripherally-acting and nondepolarizing neuromuscular blocker, is a selective antagonist of neuronal-type nicotinic AChR in ganglia that was used to treat chronic hypertension.