Tolterodine tartrate (Kabi-2234; PNU-200583E)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $480 | Check With Us |
| 1g | $850 | Check With Us |
| 5g | $2250 | Check With Us |
: Cat #: V1161 CAS #: 124937-52-6 Purity ≥ 98%
Description: Tolterodine tartrate (PNU-200583E; PNU200583E; Detrol LA; Detrusitol) is a tartrate salt of tolterodine that is a potent and competitive muscarinic receptor antagonist.
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| Molecular Weight (MW) | 475.57 |
|---|---|
| Molecular Formula | C22H31NO.C4H6O6 |
| CAS No. | 124937-52-6 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 95 mg/mL (199.8 mM)rr |
| Water: 17 mg/mL (35.7 mM)rr | |
| Ethanol: 6 mg/mL (12.6 mM) | |
| SMILES Code | OC1=CC=C(C)C=C1[C@@H](C2=CC=CC=C2)CCN(C(C)C)C(C)C.O=C(O)[C@H](O)[C@@H](O)C(O)=O |
| Synonyms | PNU-200583 E; PNU200583E; Tolterodine tartrate; PNU-200583E; PNU 200583E; Detrol LA; Detrusitol. |
| Protocol | In Vitro | Carbachol-induced contractions of isolated guinea pig bladder were effectively inhibited by tolterodine (IC50 14 nM) and 5-HM (IC50 5.7 nM). The IC50 values were in the microM range and the antimuscarinic potency of tolterodine was 27, 200 and 370-485 times higher, respectively, than its potency in blocking histamine receptors, alpha-adrenoceptors and calcium channels. The active metabolite, 5-HM, was >900 times less potent at these sites than at bladder muscarinic receptors |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1027 mL | 10.5137 mL | 21.0274 mL | 42.0548 mL |
| 5mM | 0.4205 mL | 2.1027 mL | 4.2055 mL | 8.4110 mL |
| 10mM | 0.2103 mL | 1.0514 mL | 2.1027 mL | 4.2055 mL |
| 20mM | 0.1051 mL | 0.5257 mL | 1.0514 mL | 2.1027 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.