Hexamethonium Bromide
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50g | $330 | Check With Us |
| 100g | $600 | Check With Us |
| 200g | $900 | Check With Us |
: Cat #: V1201 CAS #: 55-97-0 Purity ≥ 98%
Description: Hexamethonium Bromide (Vegolysen; Esametina; Simpatoblock), a peripherally-acting and nondepolarizing neuromuscular blocker, is a selective antagonist of neuronal-type nicotinic AChR in ganglia that was used to treat chronic hypertension.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 362.19 |
|---|---|
| Molecular Formula | C12H30N2.2Br |
| CAS No. | 55-97-0 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: <1 mg/mLrr |
| Water: 73 mg/mL (201.55 mM)rr | |
| Ethanol: <1 mg/mL | |
| SMILES Code | C[N+](CCCCCC[N+](C)(C)C)(C)C.[Br-].[Br-] |
| Synonyms | Hexamethionium bromide; Vegolysen; Esametina; Simpatoblock; |
| Protocol | In Vivo | Hexamethonium Bromide (0.2-25 mg/kg; i.v.) significantly reduces the renal sympathetic nerve activity (RSNA), mean arterial pressure (MAP) and heart rate (HR) in the Wistar rats and the spontaneously hypertensive rats (SHRs) |
|---|---|---|
| Animal model | Male normotensive Wistar rats (280-320 g), SHRs | |
| Dosages | 0.2 mg/kg, 1.0 mg/kg, 5.0 mg/kg, 25 mg/kg | |
| Administration | Intravenous injection |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7610 mL | 13.8049 mL | 27.6098 mL | 55.2196 mL |
| 5mM | 0.5522 mL | 2.7610 mL | 5.5220 mL | 11.0439 mL |
| 10mM | 0.2761 mL | 1.3805 mL | 2.7610 mL | 5.5220 mL |
| 20mM | 0.1380 mL | 0.6902 mL | 1.3805 mL | 2.7610 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.