Tropicamide

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5g	$400	Check With Us
10g	$650	Check With Us
20g	$975	Check With Us

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Cat #: V1181 CAS #: 1508-75-4 Purity ≥ 98%

Description: Tropicamide (formerly Ro-17683; Ro 1-7683; trade names Mydral; Mydriafair; Mydriaticum; Mydrum), an approved medication used to dilate the pupil and help with eye examination, is a potent anticholinergic and a muscarinic receptor isoform M4 antagonist with important biological activity. It inhibits M4-muscarinic receptor with an IC50 of 8.0 nM. It is short acting drug for mydriasis and cycloplegia when applied as eye drops.

References: Lazareno, S., N.J. Buckley, and F.F. Roberts, Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells. Mol Pharmacol, 1990. 38(6): p. 805-15.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	284.35
Molecular Formula	C17H20N2O2
CAS No.	1508-75-4
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 57 mg/mL (200.5 mM)r
	Water: <1 mg/mLr
	Ethanol: 57 mg/mL (200.5 mM)
SMILES Code	O=C(N(CC)CC1=CC=NC=C1)C(C2=CC=CC=C2)CO
Synonyms	Ro-1-7683; Ro 1 7683; Mydral; Mydriafair; Mydriaticum; Mydrum; Ro 1-7683

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.5168 mL	17.5840 mL	35.1679 mL	70.3359 mL
5mM	0.7034 mL	3.5168 mL	7.0336 mL	14.0672 mL
10mM	0.3517 mL	1.7584 mL	3.5168 mL	7.0336 mL
20mM	0.1758 mL	0.8792 mL	1.7584 mL	3.5168 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.