Corydaline

This product is for research use only, not for human use. We do not sell to patients.

Corydaline
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
50mg$600Check With Us
100mg$950Check With Us
200mg$1500Check With Us

Cat #: V11209 CAS #: 518-69-4 Purity ≥ 98%

Description: Corydaline is a bioactive and naturally occurring isoquinoline alkaloid extracted from Corydalis yanhusuo.

References: Hui-Qiang Wang, et al. Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression. J Asian Nat Prod Res. 2017 Nov;19(11):1124-1133.

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Molecular Weight (MW)369.45
Molecular FormulaC22H27NO4
CAS No.518-69-4
ProtocolIn VitroCorydaline (12.5-50 µM; 24 hours) treatment inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro
In VivoCorydaline (10 mg/kg; subcutaneous administration; once) treatment shows antinociceptive effects in mice by significantly inhibiting the writhing behavior
Animal modelMale CD1 mice (30-35 g, 7-8 weeks old) injected with acetic acid
Dosages10 mg/kg
AdministrationSubcutaneous administration; once
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.7067 mL13.5336 mL27.0673 mL54.1345 mL
5mM0.5413 mL2.7067 mL5.4135 mL10.8269 mL
10mM0.2707 mL1.3534 mL2.7067 mL5.4135 mL
20mM0.1353 mL0.6767 mL1.3534 mL2.7067 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.