Darifenacin HBr (UK88525)

This product is for research use only, not for human use. We do not sell to patients.

Darifenacin HBr (UK88525)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$550Check With Us
1g$950Check With Us
5g$2850Check With Us

Cat #: V1171 CAS #: 133099-07-7 Purity ≥ 98%

Description: Darifenacin HBr (formerly known as UK-88525; Emselex; Enablex), the hydrobromide salt of Darifenacin, is a approved medication used to treat urinary incontinence and overactive bladder.

References: Hegde SS, et al. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol, 1997, 120(8), 1409-1418.

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Product Promise

Promise
Molecular Weight (MW)507.46
Molecular FormulaC28H30N2O2.HBr
CAS No.133099-07-7
Storage-20℃ for 3 years in powder formrr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 117 mg/mL (230.5 mM)rr
Water: <1 mg/mLrr
Ethanol: <1 mg/mL
SMILES CodeO=C(N)C(C1=CC=CC=C1)([C@H]2CN(CCC3=CC4=C(OCC4)C=C3)CC2)C5=CC=CC=C5.[H]Br
SynonymsUK-88525; Darifenacin; Emselex; Enablex. UK 88525; UK88525; Darifenacin HBr
ProtocolDosages0.1 mg/kg i.v
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.9706 mL9.8530 mL19.7060 mL39.4120 mL
5mM0.3941 mL1.9706 mL3.9412 mL7.8824 mL
10mM0.1971 mL0.9853 mL1.9706 mL3.9412 mL
20mM0.0985 mL0.4926 mL0.9853 mL1.9706 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.