Ravuconazole (formerly known as BMS-207147 and ER-30346) is a novel, orally bioavailable and potent triazole antifungal agent with a broad spectrum of potent activity against a wide range of fungi. Ravuconazole is currently in phase I/II clinical trials. Ravuconazole has shown to have a similar spectrum of activity to voriconazole, with an increased half-life. In […]

Basifungin is an inositol phosphorylceramide synthase inhibitor that is extracted from the culture medium of Aureobasidium pullulans R 106.

iKIX1 is a novel and potent inhibitor of Pdr1-dependent gene activation with antifungal activity.

Levoketoconazole [(-)-Ketoconazole ((-)-R 41400)], the levo-enantiomer of Ketoconazole, is useful for treatment of Cushing’s Syndrome.

Coniferyl alcohol is an important intermediate used in biosynthesis of eugenol and of stilbene and coumarin.

AN2718 is a novel boron-containing small molecule that inhibits an essential protein synthesis enzyme, leucyl-transfer RNA synthetase, or LeuRS.

Ciclopirox (HOE-296; LACQUER; Penlac), a hydroxypyrimidine analog, is an potent, synthetic and broad-spectrum antifungal agent used for topical dermatologic treatment of superficial mycoses. It acts as an iron chelator and also inhibits the membrane transfer system by interrupting the Na+ K+ ATPase. Ciclopirox is currently being investigated as an alternative treatment to ketoconazole for seborrhoeic […]

Isavuconazole (formerly also known as BAL-4815; RO-0094815; Cresemba), a water-soluble triazole antifungal agent, is a novel and potent inhibitor of CYP3A4 with broad-spectrum antifungal activity.

Acetyllovastatin is the acetated form of Lovastatin acetate of Lovastatin, which is a statin drug for hyperlipidemia.

Liranaftate (formerly M-732; Piritetrate; Zefnart) is a thiocarbamate-based inhibitor of squalene epoxidase with fungicidal activities. It inhibits fungal squalene epoxidase, which is an enzyme that plays a key role in the synthesis of sterol, compouds essential for cell membrane integrity. By preventing ergosterol synthesis and causing accumulation of squalene, this agent increases cell membrane permeability, […]