NCB-0846 (NCB0846) is a novel, first orally bioavailable small molecule inhibitor of Wnt that inhibits TNIK (TRAF2 and NCK-Interacting Kinase) with IC50 value of 21 nM.

IWP-3 is an inactivator of Porcn function. It acts by inhibiting Wnt production.

IWP-4 is a potent inhibitor of Wnt/β-catenin signaling.

MSAB is a novel and potent inhibitor of Wnt/β-catenin signaling with anticancer activity.

WAY-262611 (WAY262611) is a novel agonist of the wingless β-Catenin pathway with the potential for the treatment of bone disorders.

iCRT 14 is a novel and potent inhibitor of β-catenin-responsive transcription (CRT) with IC50 of 40.3 nM against Wnt responsive STF16 luciferase in a homogeneous fluorescence polarization (FP) assay.

AMBMP hydrochloride is a novel and potent Wnt canonical signaling activator and tubulin polymerization inhibitor.

Adavivint (formerly known as SM04690) is a novel, potent, specific/selective inhibitor of canonical Wnt signaling pathway with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter in SW480 colon cancer cells.

PRI-724 (an analog of ICG 001 and a prodrug of C-82) is a novel, potent an specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity.

AMBMP (also known as BML-284; BML284) is a novel, potent and cell-permeable Wnt signaling activator with anti-inflammatory activity.