WAY-262611
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1020 | Check With Us |
| 500mg | $1480 | Check With Us |
| 1g | $2220 | Check With Us |
: Cat #: V3007 CAS #: 1123231-07-1 Purity ≥ 98%
Description: WAY-262611 (WAY262611) is a novel agonist of the wingless β-Catenin pathway with the potential for the treatment of bone disorders.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 318.42 |
|---|---|
| Molecular Formula | C20H22N4 |
| CAS No. | 1123231-07-1 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 42 mg/mLrr |
| Water: <1 mg/mLrr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | NCC1CCN(C2=NC=CC(C3=CC=C4C=CC=CC4=C3)=N2)CC1 |
| Synonyms | WAY 262611; WAY-262611; WAY262611; WAY-262611 HCl |
| Protocol | In Vitro | WAY-262611 has the most potent activity in the primary assay, low kinase inhibition potential, and high solubility |
|---|---|---|
| In Vivo | WAY-262611 has excellent pharmacokinetic properties and shows a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration. Calvariae from wt mice treated with WAY-262611 shows statistically increased BFR, while similarly treated KO animals are no different from control. This indicates that WAY-262611 is acting via the Wnt β-catenin pathway and most likely through inhibition of Dkk-1 |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.1405 mL | 15.7025 mL | 31.4051 mL | 62.8101 mL |
| 5mM | 0.6281 mL | 3.1405 mL | 6.2810 mL | 12.5620 mL |
| 10mM | 0.3141 mL | 1.5703 mL | 3.1405 mL | 6.2810 mL |
| 20mM | 0.1570 mL | 0.7851 mL | 1.5703 mL | 3.1405 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.