iCRT14
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $745 | Check With Us |
| 500mg | $1200 | Check With Us |
| 1g | $1800 | Check With Us |
: Cat #: V5249 CAS #: 677331-12-3 Purity ≥ 98%
Description: iCRT 14 is a novel and potent inhibitor of β-catenin-responsive transcription (CRT) with IC50 of 40.3 nM against Wnt responsive STF16 luciferase in a homogeneous fluorescence polarization (FP) assay.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 375.44 |
|---|---|
| Molecular Formula | C21H17N3O2S |
| CAS No. | 677331-12-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent |
| Protocol | In Vitro | iCRT14 can interfere with TCF binding to DNA in addition to its ability to influence TCF-β-cat interaction. iCRT14 (10, 25, 50 μM) effectively inhibits cell proliferation in BT-549 cells in a dose- and time-dependent manner, but still less potent than iCRT3 |
|---|---|---|
| In Vivo | iCRT14 (50 mg/kg, i.p.) markedly decreases CycD1, proliferation of the tumors in HCT116 xenografts |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6635 mL | 13.3177 mL | 26.6354 mL | 53.2708 mL |
| 5mM | 0.5327 mL | 2.6635 mL | 5.3271 mL | 10.6542 mL |
| 10mM | 0.2664 mL | 1.3318 mL | 2.6635 mL | 5.3271 mL |
| 20mM | 0.1332 mL | 0.6659 mL | 1.3318 mL | 2.6635 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
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Step Two: Enter the in vivo formulation
%DMSO
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%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.