PNU-74654 (PNU74654) is a novel inhibitor of Wnt/β-catenin pathway (IC50 = 129.8 μM), acting by inhibiting the interaction between ß-catenin and T cell factor 4 (Tcf4), and disrupting the Wnt signaling pathway.

Tegatrabetan(also known as Tegavivint; BC-2059; BC 2059; BC2059) is an orally bioavailable and potent β-catenin inhibitor with potential anticancer activity.

KY1220 is a small molecule that simultaneously degrades β-catenin and Ras by inhibition of the Wnt/β-catenin pathway.

Cardiogenol C is a diaminopyrimidine compound that induces the differentiation of MHC- (myosin heavy chain) positive cardiomyocytes from embryonic stem cells with an EC50 of 0.1 µM.

CCT251545 is a novel, potent, selective and orally bioavailable small-molecule inhibitor of WNT signaling with an IC50 of 5 nM in 7dF3 cells.

Cardiogenol C is a novel and potent pyrimidine inducer.

KYA1797K is a novel highly potent and selective inhibitor of both Wnt/ß-catenin and Ras pathways.

IQ-1 (IQ1) is a cell-permeable tetrahydroisoquinolinylidene small molecule compound that modulates Wnt/beta-catenin signaling.

HLY78 is a novel and potent small molecule activator of the Wnt/β-catenin signaling pathway which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction.

Salinomycin (also known as AHR-3096, or Procoxacin) is a potent antibacterial and coccidiostat ionophore therapeutic agent with potential anticancer activities by targeting stem cells.