Primidone (also known as NCI-C56360; NCIC56360; Mylepsinum; Mizodin; Primaclone; Mysoline; Resimatil), an analog of phenobarbital, is an anticonvulsant of the barbiturate class.
PF-05089771 (PF05089771) is a potent and subtype selective NaV1.7 inhibitor (IC50 = 11 nM) and Nav1.8 voltage-gated sodium channel blocker with the potential to be used in the treatment of chronic neuropathic pain.
PF-06305591 is a novel, potent and highly selective blocker of voltage gated sodium channel NaV1.8 with an IC50 of 15 nM and with excellent ADME and safety profiles.
Ouabain (Ouabain Octahydrate; Acocantherine; G-Strophanthin; Strodival; NSC-25485; NSC25485) is a novel, potent and selective Na+/K+, -ATPase inhibitor with the potential to treat heart failure due to myocardial infarction.
Phenytoin Sodium (also known as 5,5-Diphenylhydantoin; Diphenylhydantoin Sodium; Diphantoine), the sodium salt of Phenytoin, is an inactive voltage-gated sodium channel stabilizer.
Cilnidipine (formerly also known as FRC-8653; FRC8653; Atelec; Cinalong; Siscard) is a novel, potent and unique dual L-type and N-type calcium channel blocker (CCB) that was approved as an anti-hypertensive drug in 1995 for high blood pressure treatment.
PF-05089771 Tosylate, the tosylate salt of PF05089771, is a potent and subtype selective NaV1.7 inhibitor with IC50 of 11 nM.
Amiloride HCl (MK-870; Midamor; Midoride; Modamide), the hydrochloride salt of amiloride, is a potent and relatively selective inhibitor of the epithelial sodium channel (ENaC) with anti-hypertensive activity.
Triamterene (formerly SKF-8542; SKF8542; BRN-0266723; Dyrenium; Diucelpin; Diurene) is a diuretic commonly used in combination with thiazide diuretics (e.g. hydrochlorothiazide/triamterene) for the treatment of high blood pressure or swelling.
Bulleyaconitine A (also known as Bulleyaconi cine A) is a potent analgesic and antiinflammatory drug isolated from aconitum plant displays long-acting local anesthetic properties in vitro and in vivo.