Cilnidipine (FRC8653)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$250	Check With Us
10g	$1190	Check With Us
20g	$1785	Check With Us

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Cat #: V1650 CAS #: 132203-70-4 Purity ≥ 98%

Description: Cilnidipine (formerly also known as FRC-8653; FRC8653; Atelec; Cinalong; Siscard) is a novel, potent and unique dual L-type and N-type calcium channel blocker (CCB) that was approved as an anti-hypertensive drug in 1995 for high blood pressure treatment.

References: S Fujii,et al. Effect of cilnidipine, a novel dihydropyridine Ca²⁺-channel antagonist, on N-type Ca²⁺ channel in rat dorsal root ganglion neurons. J Pharmacol Exp Ther. 1997 Mar;280(3):1184-91.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	492.52
Molecular Formula	C27H28N2O7
CAS No.	132203-70-4
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 99 mg/mL (201.0 mM)r
	Water: <1 mg/mLr
	Ethanol: 15 mg/mL (30.5 mM)
Solubility In Vivo	5% DMSO+Corn oil: 7 mg/mL
Synonyms	FRC-8653; Cilnidipine; Atelec; Cinalong; Siscard; FRC 8653; FRC8653.

Protocol	In Vitro	Cilnidipine inhibits the L-type current with an IC50 of 100 nM in neurons pretreated with omegaCgTx plus omegaAgTx. The IC50 for Cilnidipine in respect of the N-type current is 200 nM.
Protocol	In Vivo	Cilnidipine has potent inhibitory actions on N-type as well as L-type voltage-dependent Ca2+-channel in rat dorsal root ganglion neurons

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.0304 mL	10.1519 mL	20.3037 mL	40.6075 mL
5mM	0.4061 mL	2.0304 mL	4.0607 mL	8.1215 mL
10mM	0.2030 mL	1.0152 mL	2.0304 mL	4.0607 mL
20mM	0.1015 mL	0.5076 mL	1.0152 mL	2.0304 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.