Triamterene (SKF8542)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5g	$200	Check With Us
10g	$320	Check With Us
20g	$480	Check With Us

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Cat #: V1668 CAS #: 396-01-0 Purity ≥ 98%

Description: Triamterene (formerly SKF-8542; SKF8542; BRN-0266723; Dyrenium; Diucelpin; Diurene) is a diuretic commonly used in combination with thiazide diuretics (e.g. hydrochlorothiazide/triamterene) for the treatment of high blood pressure or swelling.

References: Busch, A.E., et al., Blockade of epithelial Na+ channels by triamterenes - underlying mechanisms and molecular basis. Pflugers Arch, 1996. 432(5): p. 760-6.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	253.26
Molecular Formula	C12H11N7
CAS No.	396-01-0
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 20 mg/mL (79 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Solubility In Vivo	0.5% CMC Na+1% Tween 80: 30 mg/mL
Synonyms	SKF-8542; BRN 0266723; SKF 8542; BRN0266723; SKF8542; BRN-0266723; Triamterene; Diucelpin; Diurene

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.9485 mL	19.7426 mL	39.4851 mL	78.9702 mL
5mM	0.7897 mL	3.9485 mL	7.8970 mL	15.7940 mL
10mM	0.3949 mL	1.9743 mL	3.9485 mL	7.8970 mL
20mM	0.1974 mL	0.9871 mL	1.9743 mL	3.9485 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.