PF-04531083 (PF04531083) is a novel, potent and selective NaV1.8 blocker with the potential to be used for neuropathic/inflammatory pain.

Tolperisone HCl (AV650; AV-650; N553; Midocalm; Muscalm; Mydocalm), the hydrochloride salt of tolperisone, is an ion channel blocker and centrally-acting muscle relaxant.

Ibutilide fumarate (formerly known as U 70226 E; U-70226-E; U-70226E), the fumarate salt of Ibutilide, is a Class III antiarrhythmic agent that has been used for treating acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current.