ML335 (ML-335) is a potent and selective activator of TREK-1/-2 and an agonist for OPRM1-OPRD1 (OPRM1: opioid receptor mu 1; OPRD1: delta opioid receptor) heterdimerization.

Doxapram hydrochloride (AHR619) is a respiratory stimulant that can also inhibit TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.

ML213 (formerly known as CID-3111211) is a potent and selective activator/opener of Kv7.2 (KCNQ2) and Kv7.4 (KCNQ4) channels which enhances Kv7.2 and Kv7.4 channels with EC50 of 230 and 510 nM, respectively.

NS1643 is a novel and potent human ether-a-go-go related gene (hERG) KV11 channel activator with EC50 of 10.5 μM.

Senicapoc, formerly known as ICA-17043, is a highly potent Gardos Channel (Ca2+-activated K+ channel; KCa3.1) inhibitor/blocker with an IC50 of 11 nM, and with the potential for the treatment of a subset of Hereditary Xerocytosis caused by mutations in the Gardos channel.

ML297 is a truly potent and selective GIRK channel agonist with IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively.

Indapamide (Natrilix, Noranat, Fludex, Tertensif) is a potent thiazide-like diuretic used in the treatment of hypertension, as well as decompensated cardiac failure.

SKA-31 is a novel and potent activator of KCa2 and KCa3.1 calcium-activated potassium channels with blood pressure-lowering effects.

Doxapram (AHR619, Dopram, Stimulex or Respiram) is a novel potent respiratory stimulant that acts by inhibiting the potassium channels such as TASK-1, TASK-3, TASK-1/TASK-3 with EC50 of 410 nM, 37 μM, 9 μM, respectively.

NS-5806 (NS5806) is a novel and potent potassium current KV4.3 channel activator which increases KV4.3/KChIP2 peak current amplitudes with an EC50 of 5.3 μM.