NS-1643
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $650 | Check With Us |
| 500mg | $999 | Check With Us |
| 1g | $1500 | Check With Us |
: Cat #: V2831 CAS #: 448895-37-2 Purity ≥ 98%
Description: NS1643 is a novel and potent human ether-a-go-go related gene (hERG) KV11 channel activator with EC50 of 10.5 μM.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 380.24 |
|---|---|
| Molecular Formula | C₁₅H₁₀F₆N₂O₃ |
| CAS No. | 448895-37-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mMr |
| Water: N/Ar | |
| Ethanol: N/A | |
| Synonyms | NS-1643; NS 1643; NS1643. |
| Protocol | In Vitro | NS1643 (10 and 50 μM) dose-dependently inhibits migration and invasion of MDA-MB-231 and SKBR3 cancer cells |
|---|---|---|
| In Vivo | NS1643 (6 mg/kg； Intraperitoneal injection, twice a week) inhibits breast tumor metastasis | |
| Animal model | NSG mice with human-derived TNBC tumor xenografts | |
| Dosages | 6 mg/kg | |
| Administration | Intraperitoneal injection; 6 mg/kg; twice per week |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6299 mL | 13.1496 mL | 26.2992 mL | 52.5984 mL |
| 5mM | 0.5260 mL | 2.6299 mL | 5.2598 mL | 10.5197 mL |
| 10mM | 0.2630 mL | 1.3150 mL | 2.6299 mL | 5.2598 mL |
| 20mM | 0.1315 mL | 0.6575 mL | 1.3150 mL | 2.6299 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.