PA-6 is a selective and potent IK1 (inward rectifier potassium current) inhibitor that terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models.
BAPTA-AM is a selective, membrane-permeable and intracellular calcium chelator.
BMS-191095 is a novel and potent activator of mitochondrial ATP-sensitive potassium (mitoKATP) channels.
NS6180 is a novel potent and selective KCa3.1 channel inhibitor with IC50 of 9 nM.
This product has been discontinued. Verdinexor (formerly KPT-335; KPT 335; KPT335) is an orally bioavailable, selective XPO1/CRM1 (Exportin 1/Chromosomal Maintenance 1) inhibitor with potential antineoplastic activity. Verdinexor inhibited proliferation, blocked colony formation, and induced apoptosis of treated cells at biologically relevant concentrations of drug. Additionally, Verdinexor downregulated XPO1 protein while inducing a concomitant increase in […]
E-4031 diHCl (E4031 dihydrochloride) is a novel, potent and selective blocker of hERG K+ channels, which is also termed as a class III antiarrhythmic agent.
Nifekalant hydrochloride (MS-551) is an IKr potassium channel blocker belonging to the class III antiarrhythmic agent with an IC50 of 10 µM.
ML277 (formerly known as CID53347902) is a novel, potent and selective activator of the K(v)7.1 (KCNQ1) potassium channel with EC50 of 270 nM.
CLP-290 is a novel and potent KCC2 modulator acting as a prodrug of CLP-257, and is highly selective for KCC2 over related Cl- transporters.
ICA-27243 is a novel and potent activator of M-current and KCNQ2/Q3 channels