ML213
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $750 | Check With Us |
| 500mg | $1250 | Check With Us |
| 1g | $1875 | Check With Us |
: Cat #: V3227 CAS #: 489402-47-3 Purity ≥ 98%
Description: ML213 (formerly known as CID-3111211) is a potent and selective activator/opener of Kv7.2 (KCNQ2) and Kv7.4 (KCNQ4) channels which enhances Kv7.2 and Kv7.4 channels with EC50 of 230 and 510 nM, respectively.
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| Molecular Weight (MW) | 257.38 |
|---|---|
| Molecular Formula | C17H23NO |
| CAS No. | 489402-47-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: > 30 mg/mLr |
| Water:r | |
| Ethanol: | |
| SMILES Code | O=C(C1CC2CCC1C2)NC3=C(C)C=C(C)C=C3C |
| Synonyms | ML-213; ML 213; ML213; CID-3111211; CID 3111211; CID3111211 |
| Protocol | In Vitro | ML213 (100 nM-30 µM) increases maximal conductance to a peak at 212% ± 27% of control, with an EC50 of 0.8 ± 0.3 µM. ML213 (10 µM) reduces the deactivation rates of Kv7.4 currents by 4.6-fold in the voltage range from −130 mV to −90 mV. ML213 is a potent and effective activator of homomeric Kv7.5 channels overexpressed in A7r5 cells. ML213 increases maximal conductance of Kv7.5 channels with an EC50 of 0.7 ± 0.2 µM. ML213 (10 µM) also reduces deactivation rates of Kv7.5 currents by 5.9-fold on average. ML213 produces similar effects on heteromeric Kv7.4/7.5 channels: 204% ± 11% maximal increase in conductance with an EC50 of 1.1 ± 0.6 µM and a 34.2 ± 3.3 mV maximal negative shift of the activation curve, with an EC50 of 3.8 ± 1.2 µM |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.8853 mL | 19.4265 mL | 38.8531 mL | 77.7061 mL |
| 5mM | 0.7771 mL | 3.8853 mL | 7.7706 mL | 15.5412 mL |
| 10mM | 0.3885 mL | 1.9427 mL | 3.8853 mL | 7.7706 mL |
| 20mM | 0.1943 mL | 0.9713 mL | 1.9427 mL | 3.8853 mL |
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%
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%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
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mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.