ML297
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1000 | To Be Confirmed |
| 500mg | $1650 | To Be Confirmed |
| 1g | $2475 | To Be Confirmed |
: Cat #: V4034 CAS #: 1443246-62-5 Purity ≥ 98%
Description: ML297 is a truly potent and selective GIRK channel agonist with IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 328.32 |
|---|---|
| Molecular Formula | C17H14F2N4O |
| CAS No. | 1443246-62-5 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10mMrr |
| Water: N/Arr | |
| Ethanol: N/A | |
| SMILES Code | O=C(NC1=CC(C)=NN1C2=CC=CC=C2)NC3=CC=C(F)C(F)=C3InChI=1S/C17H14F2N4O/c1-11-9-16(23(22-11)13-5-3-2-4-6-13)21-17(24)20-12-7-8-14(18)15(19)10-12/h2-10H,1H3,(H2,20,21,24) |
| Synonyms | ML297; ML 297; ML-297. |
| Protocol | In Vitro | ML297 shows a complete inability to modulate the activity of HEK-293 cells expressing GIRK2 alone and GIRKGIRK2/3 |
|---|---|---|
| In Vivo | ML297 (60 mg/kg; i.p.) shows a highly significant ability to both prevent convulsions and prevent fatality of the PTZ treatment | |
| Animal model | 8-10 months old C57/BL6 male mice (approximately 30 g) | |
| Dosages | 60 mg/kg | |
| Administration | Intraperitoneal injection |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.0458 mL | 15.2290 mL | 30.4581 mL | 60.9162 mL |
| 5mM | 0.6092 mL | 3.0458 mL | 6.0916 mL | 12.1832 mL |
| 10mM | 0.3046 mL | 1.5229 mL | 3.0458 mL | 6.0916 mL |
| 20mM | 0.1523 mL | 0.7615 mL | 1.5229 mL | 3.0458 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.