Irsogladine (MN1695; MN 1695; Gaslon; MN-1695; Dicloguamine), a mucosal protective drug, is a novel and potent PDE4 inhibitor and muscarinic acetylcholine receptor binder with anti-ulceric activity.

Udenafil (formerly known as DA8159) is a novel and potent PDE5 inhibitor used in urology to treat erectile dysfunction.

Sildenafil Mesylate (formerly UK-92480; UK92480; Revatio; VIAGRA), the mesylate salt form of Sildenafil, is deemed as the best treatment for erectile dysfunction.

Cilostazol (formerly OPC-13013; Pletal; Cilostazolum; Pletaal; OPC13013; OPC 13013), a potent vasodilator that acts by relaxing the muscles, is a selective cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with beneficial effects on learning impairment.

Doxofylline (also known as Neothylline; Ansimar; ABC-1213; ALT-07; Lufyllin; DO-309; Diprophylline; Corphyllin; ABC-12-3), a xanthine derivative, is a novel and potent PDE (phosphodiesterase) inhibitor with the potential for treating asthma.

Ibudilast (formerly known as KC-404, AV-411 or MN-166) is a potent and nonspecific/nonselective inhibitor of the phosphodiesterase (PDE).

Mardepodect (formerly known as PF-2545920, PF2545920, MP10; MP-10) is a novel, potent and selective PDE10A (phosphodiesterase) inhibitor with antipsychotic activity.

RO2959 is a novel, potent and highly selective CRAC current inhibitor (IC50 of 402 nM), also a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC50 of 25 nM. .

S-(+)-Rolipram, the S-isomer of rolipram (ME3167; SB-95952; ZK62711), is a potent phosphodiesterase PDE4-inhibitor with potent anti-inflammatory and anti-depressant activity.

Crisaborole (formerly known as AN-2728; PF-06930164; AN2728; PF06930164; trade name: Eucrisa) is a potent and selective PDE4 (phosphodiesterase 4) inhibitor with a broad-spectrum of anti-inflammatory activity.