Rolipram (formerly called ME-3167; ZK-62711; SB95952; the racemic mixture of R- and S-rolipram) is a novel, potent and selective phosphodiesterase PDE4 inhibitor with potential anti-inflammatory and anti-depressant activity.

PF-8380 is a novel, potent and specific autotaxin (ATX) inhibitor with an IC50 of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood.

Tadalafil (formerly known as IC351; IC-351; trade name Cialis) is a potent, orally bioavailable, reversible and competitive small-molecule inhibitor of PDE-5 (phosphodiesterase 5) with the potential to treat erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension.

Fenspiride (NAT-333; JP-428; NDR-5998A; Decaspiride; Espiran; trade names Eurespal, Pneumorel), an oxazolidinone spiro compound acting as a α adrenergic and H1 histamine receptor antagonist, is a bronchodilator with potent anti-inflammatory properties.

Anagrelide HCl (formerly BL4162A; BL-4162A; BL-4162-A; trade names Agrylin/Xagrid, Shire and Thromboreductin), the hydrochloride salt of Anagrelide, is an approved drug used for the treatment of essential thrombocytosis (thrombocythemia) and overproduction of blood platelets.

Avanafil (also known as TA 1790; TA1790; TA-1790; trade name: Stendra; Spedra) is a highly potent and selective PDE5 inhibitor with potential vasodilating effects.

Aminophylline (also known as Phyllocontin; Euphyllin; Truphylline), a bronchodilator composed of theophyllineand ethylenediamine in 2:1 ratio, is a novel, potent, competitive nonselective phosphodiesterase/PDE inhibitor with an IC50 of 0.12 mM.

Cilomilast (also known as SB-207,499; SB207499; trade name Ariflo) is a novel, potent and orally bioactive phosphodiesterase 4/PDE4 inhibitor with potential anti-inflammatory and immunomodulatory activity.