Luteolin (also known as Digitoflavone; Salifazide; BRN0292084; RN 0292084; Luteolol) is a naturally occuring flavonoid isolated from plants such as Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki values of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively.

GSK256066 (GSK-256066; GSK 256066) is a novel, potent and selective inhibitor of PDE4B (phosphodiesterase 4B) with important biological activity (e.g. inhibiting pulmonary neutrophilia).

Dipyridamole (also known as NSC515776; RA8; Persantine) is a pyrimido-pyrimidine based phosphodiesterase (PDE) inhibitor with antiplatelet properties.

Sildenafil Citrate (formerly also known as UK-92480 citrate; Trade names Revatio; VIAGRA among others), the citrate form of Sildenafil, is a potent and selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) with IC50 of 5.22 nM.

Pimobendan (UD-CG115; UDCG115; Trade names Vetmedin, Acardi), a veterinary medication approved to treat CHF-congestive heart failure in dogs, is a potent and selective inhibitor of phosphodiesterase PDE3 with positive inotropic and vasodilator effects.

Balipodect (formerly also known as TAK-063) is a novel, highly potent, orally bioavailable and selective phosphodiesterase 10A (PDE10A) inhibitor with potential usefulness in the treatment of schizophrenia.

Lotamilast (formerly RVT-501; E-6005) is a novel, potent and selective inhibitor of phosphodiesterase 4 (PDE-4, IC50 = 2.8 nM) with the potential to be used for the treatment of AD/atopic dermatitis.

Roflumilast (BY-217; APTA-2217; B 9302-107; BYK20869; Daxas; Daliresp) is a novel, highly potent, selective, and long-acting inhibitor of phosphodiesterase 4/PDE4 with potential anti-inflammatory activity.

Vardenafil (also known as BAY 38-9456; trade names: Levitra; Staxyn; Vivanza) is a novel and potent PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.

Mardepodect HCl, the hydrochloric acid salt of PF-2545920 (Also known as Mardepodect, MP-10), is a novel, potent and selective PDE10A (phosphodiesterase) inhibitor with IC50 of 0.37 nM, and with >1000-fold selectivity over the PDE. It is potentially useful for the treatment of schizophrenia. PF-2545920 is active in a range of antipsychotic models, antagonizing apomorphine-induced climbing […]