Lotamilast (RVT501; E6005)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $700 | Check With Us |
| 250mg | $1200 | Check With Us |
| 500mg | $1800 | Check With Us |
: Cat #: V14147 CAS #: 947620-48-6 Purity ≥ 98%
Description: Lotamilast (formerly RVT-501; E-6005) is a novel, potent and selective inhibitor of phosphodiesterase 4 (PDE-4, IC50 = 2.8 nM) with the potential to be used for the treatment of AD/atopic dermatitis.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 472.49 |
|---|---|
| Molecular Formula | C26H24N4O5 |
| CAS No. | 947620-48-6 |
| SMILES Code | O=C(OC)C1=CC=C(C(NC2=CC=CC(C3=C4C=C(OC)C(OC)=CC4=NC(NC)=N3)=C2)=O)C=C1 |
| Synonyms | E-6005; E6005; E6005; RVT-501; RVT501; RVT 501; lotamilast; |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1164 mL | 10.5822 mL | 21.1645 mL | 42.3289 mL |
| 5mM | 0.4233 mL | 2.1164 mL | 4.2329 mL | 8.4658 mL |
| 10mM | 0.2116 mL | 1.0582 mL | 2.1164 mL | 4.2329 mL |
| 20mM | 0.1058 mL | 0.5291 mL | 1.0582 mL | 2.1164 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.