Deltarasin (also known as Deltarasin hydrochloride) is a novel, high affinity and potent small molecule inhibitor of KRAS-PDEδ protein-protein interaction with potential antineoplastic activity.

Enpp-1-IN-1 (extracted from patent WO2019046778, Example 55) is a potent inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1).

Dyphylline (also named as Diprophylline; Corphyllin; Lufyllin; Neothylline), a xanthine derivative with bronchodilator and vasodilator effects, is used in the treatment of respiratory disorders like cardiac dyspnea, asthma, and bronchitis.

Milrinone (formerly known as Win-47203; Win 47203; trade name Primacor) is a potent and selective phosphodiesterase 3 (PDE3) inhibitor that is used as a pulmonary vasodilator to increase the heart’s contractility.

Apremilast (also known as CC-10004), a thalidomide analog, is a novel and orally bioavailable small molecule inhibitor of the phosphodiesterase 4 (PDE4) with potential anti-inflammatory activity.

Diosgenin is a plant steroidal sapogenin which induces apoptosis in colon cancer cell lines and induces apoptosis,cell cycle arrest and COX activity in osteosarcoma cells.

Vardenafil HCl Trihydrate (formerly also known as BAY 38-9456, trade names Levitra; Staxyn; Vivanza) is an approved medication acting as a phosphodiesterase/PDE inhibitor with important biological activity.

Ziritaxestat (formerly GLPG1690) is a potent and a first-in-class selective autotaxin (ATX) inhibitor (IC50 = 131 nM and Ki of 15 nM) with the potential to be used in the treatment of idiopathic pulmonary disease (IPF).

Icariin (also called Ieariline), a naturally occuring flavonol glycoside found in Epimedium (a Chinese medicinal herb), is a potent cGMP-specific Phosphodiesterase PDE5 inhibitor with important biological activity.

Pentoxifylline (also known as oxpentifylline, theobromine, dimethyloxohexylxanthine, EHT 0202, BL 191, BL-191; PTX, pentoxifilina, Trental), a xanthine derivative, is a nonselective PDE inhibitor used as a drug to treat muscle pain in people with peripheral artery disease.