Cilomilast (SB207499; Ariflo)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1050 | Check With Us |
| 500mg | $1550 | Check With Us |
| 1g | $2325 | Check With Us |
: Cat #: V0779 CAS #: 153259-65-5 Purity ≥ 98%
Description: Cilomilast (also known as SB-207,499; SB207499; trade name Ariflo) is a novel, potent and orally bioactive phosphodiesterase 4/PDE4 inhibitor with potential anti-inflammatory and immunomodulatory activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 343.42 |
|---|---|
| Molecular Formula | C20H25NO4 |
| CAS No. | 153259-65-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 69 mg/mL (200.9 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 50 mg/mL (145.6 mM) | |
| Solubility In Vivo | 5% DMSO+95% Corn oil: 30 mg/mL |
| SMILES Code | O=C([C@H]1CC[C@](C2=CC=C(OC)C(OC3CCCC3)=C2)(C#N)CC1)O |
| Synonyms | Cilomilast; SB 207499; SB207499; Ariflo; SB-207499; |
| Protocol | In Vitro | Cilomilast (0.1 nM-10 μM; 5 min) inhibits human neutrophil functions. |
|---|---|---|
| In Vivo | SB-207499 (500 μg/ear; b.i.d. for 6 d) inhibits the chronic oxazolone-induced inflammatory response and intralesional IL-4 concentrations in mice. | |
| Animal model | SB-207499 (0.1-100 mg/kg; oral gavage) reverses reserpine-induced hypothermia in mice, with an ED50 of 2.3 mg/kg. SB-207499 (500 μg/ear; b.i.d. for 6 d) inhibits the chronic oxazolone-induced inflammatory response and intralesional IL-4 concentrations in mice. SB-207499 (1-100 mg/kg; p.o.) significantly inhibits the production of human TNFα in a dose-dependent manner in mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9119 mL | 14.5594 mL | 29.1189 mL | 58.2377 mL |
| 5mM | 0.5824 mL | 2.9119 mL | 5.8238 mL | 11.6475 mL |
| 10mM | 0.2912 mL | 1.4559 mL | 2.9119 mL | 5.8238 mL |
| 20mM | 0.1456 mL | 0.7280 mL | 1.4559 mL | 2.9119 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.