Anagrelide HCl

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$880	Check With Us
1g	$1350	Check With Us
5g	$3415	Check With Us

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Cat #: V0789 CAS #: 58579-51-4 Purity ≥ 98%

Description: Anagrelide HCl (formerly BL4162A; BL-4162A; BL-4162-A; trade names Agrylin/Xagrid, Shire and Thromboreductin), the hydrochloride salt of Anagrelide, is an approved drug used for the treatment of essential thrombocytosis (thrombocythemia) and overproduction of blood platelets.

References: Pescatore, S.L. and C. Lindley, Anagrelide: a novel agent for the treatment of myeloproliferative disorders. Expert Opin Pharmacother, 2000. 1(3): p. 537-46.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	292.55
Molecular Formula	C10H7Cl2N3O.HCl
CAS No.	58579-51-4
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 14 mg/mL (47.9 mM)r
	Water:<1 mg/mLr
	Ethanol: <1 mg/mL
SMILES Code	O=C1NC2=NC3=C(C(Cl)=C(Cl)C=C3)CN2C1.[H]Cl
Synonyms	BL-4162A; Anagrelide hydrochloride; BL 4162A; BL-4162A; BL4162A; Agrylin; Xagrid; GALE-401; Thromboreductin

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.4182 mL	17.0911 mL	34.1822 mL	68.3644 mL
5mM	0.6836 mL	3.4182 mL	6.8364 mL	13.6729 mL
10mM	0.3418 mL	1.7091 mL	3.4182 mL	6.8364 mL
20mM	0.1709 mL	0.8546 mL	1.7091 mL	3.4182 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.