Ibudilast (KC404, AV411， MN166)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $210 | In Stock |
| 1g | $340 | In Stock |
| 5g | $860 | In Stock |
: Cat #: V3145 CAS #: 50847-11-5 Purity ≥ 98%
Description: Ibudilast (formerly known as KC-404, AV-411 or MN-166) is a potent and nonspecific/nonselective inhibitor of the phosphodiesterase (PDE).
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| Molecular Weight (MW) | 230.31 |
|---|---|
| Molecular Formula | C14H18N2O |
| CAS No. | 50847-11-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 46 mg/mL (199.7 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 46 mg/mL (199.7 mM) | |
| Solubility In Vivo | ~2.7 mg/mL in 10% DMSO : 90% (20% SBE-β-CD in saline) ~2.7 mg/mL in 10% DMSO : 40% PEG300 : 5% Tween-80 : 45% saline ~2.7 mg/mL in 10% DMSO : 90% corn oil |
| SMILES Code | CC(C)C(C1=C2C=CC=CN2N=C1C(C)C)=O |
| Synonyms | Ibudilast; AV-411, KC-404; KC 404; MN-166, AV 411, AV411, KC404; MN166, MN 166 Chemical Name: 2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one Exact Mass: 230.1419 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.3420 mL | 21.7099 mL | 43.4197 mL | 86.8395 mL |
| 5mM | 0.8684 mL | 4.3420 mL | 8.6839 mL | 17.3679 mL |
| 10mM | 0.4342 mL | 2.1710 mL | 4.3420 mL | 8.6839 mL |
| 20mM | 0.2171 mL | 1.0855 mL | 2.1710 mL | 4.3420 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.