TAS-103 dihydrochloride (also known as BMS-247615) is a potent and dual inhibitor of DNA topoisomerase I/II.

Ciprofloxacin (formerly known as Bay-09867; Bay09867; Baflox; Cetraxal; Ciprolin; Fimoflox; Proflaxin; Spitacin) is a broad-spectrum, fluoroquinolone class of antibiotic/antimicrobial which shows an MIC90 (minimal inhibitory concentrations for 90%) of between 0.008 and 2 μg/ml against various bacteria including Enterobacteriaceae, Haemophilus influenzae, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Staphylococcus aureus, streptococci, and Bacteroidesfragilis strains.

10-Hydroxycamptothecin (also abbreviated as 10HCPT; 10OHCPT; HCPT; 10 HCPT), the 10-hydroxylated form of camptothecin, is a natural product and topoisomerase I inhibitor with potential anticancer activity.

Clinafloxacin (formerly also known as CI-960, PD-127391, AM-1091; CI 960, PD127391, AM1091) is a broad-spectrum and investigational antibiotic of the fluoroquinolone class with promising antibiotic activity against gram-positive, gram-negative, and anaerobic pathogens.

Idarubicin HCl (NSC-256439; IMI 30; NSC 256439; 4-DMDR; IDA; 4-Demethoxydaunomycin; Idamycin), the hydrochloride salt form of Idarubicin, is a potent anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor approved for use as an anticancer drug.

AQ4 is a novel and potent topoisomerase II inhibitor and DNA intercalator with anticancer activities.

GSKJ1 (GSK-J1; GSK-J 1; GSK-J-1) is a novel, highly selective and potent inhibitor of histone demethylase (H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A) with potential antineoplastic activity.

Camptothecin (also known as Campathecin; CPT; NSC-100880), a naturally occurring quinoline alkaloid, is a potent and specific inhibitor of DNA enzyme topoisomerase I (Topo I) with potent antitumor activity.

Berberine HCl (Natural Yellow 18 chloride), an isoqinoline alkaloid extracted from the Chinese herbal medicine Huanglian, is a quaternary ammonium salt from the group of isoquinoline alkaloids with varoius biological activities.

SN-38 (NK012; SN-38; NK-012; SN 38; 10-hydroxy-7-ethylcamptothecin) is the active metabolite of Irinotecan (CPT-11) which is a Topoisomerase I inhibitor approved for use as an anticancer drug.