Idarubicin HCl

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$1850	Check With Us
1g	$2950	Check With Us
5g	$8700	Check With Us

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Cat #: V1394 CAS #: 57852-57-0 Purity ≥ 98%

Description: Idarubicin HCl (NSC-256439; IMI 30; NSC 256439; 4-DMDR; IDA; 4-Demethoxydaunomycin; Idamycin), the hydrochloride salt form of Idarubicin, is a potent anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor approved for use as an anticancer drug.

References: Orlandi P, et al. Idarubicin and idarubicinol effects on breast cancer multicellular spheroids. J Chemother. 2005 Dec;17(6):663-7.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	533.95
Molecular Formula	C26H27NO9.HCl
CAS No.	57852-57-0
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 100 mg/mL (187.3 mM)r
	Water: 7 mg/mL warmed (13.1 mM)r
	Ethanol: <1 mg/mL
Synonyms	4-demethoxydaunorubicin (NSC256439, 4-DMDR) HCl; IMI30; NSC256439; IMI-30; NSC-256439; IMI 30; NSC 256439; 4-DMDR; IDA; 4-Demethoxydaunomycin; brand name: Idamycin; IDAMYCIN PFS.

Protocol	In Vitro	The IC50 of idarubicin is 3.3±0.4 ng/mL on MCF-7 monolayers and 7.9±1.1 ng/mL in multicellular spheroids

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.8728 mL	9.3642 mL	18.7283 mL	37.4567 mL
5mM	0.3746 mL	1.8728 mL	3.7457 mL	7.4913 mL
10mM	0.1873 mL	0.9364 mL	1.8728 mL	3.7457 mL
20mM	0.0936 mL	0.4682 mL	0.9364 mL	1.8728 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.