Pixantrone (formerly known as BBR 2778), is a novel, potent aza-anthracenedione analog with anticancer activity with little cardiotoxicity.

Nalidixic acid (formerly known as NSC-82174; NSC82174; Nevigramon, Neggram, Wintomylon, WIN 18,320), a synthetic 1,8-naphthyridine antimicrobial agent used to treat infections, is the first synthetic quinolone-based antibiotic with a narrow spectrum of bacteriocidal effects.

Mitoxantrone (formerly known as NSC-301739; CL232325; Mitozantrone; Novantrone; Mitroxone; Neotalem; Onkotrone; Pralifan), the hydrochloride salt of Mitoxantrone which is an approved anticancer medication, is a potent type II topoisomerase inhibitor with potential antitumor activity.

Dxd, an exatecan analog, is a novel and potent DNA topoisomerase I inhibitor(IC50=0.31 μM) with anticancer activity, and is used as a conjugated drug of HER2-targeting ADC (DS-8201a).

Rubitecan (RFS-2000), a semisynthetic camptothecin analog, is an orally bioactive topoisomerase I inhibitor antitumor and antiviral activity.

Topotecan HCl (formerly known as NSC609699, Nogitecan, NSC-609699, SKFS-104864A; trade name: Hycamtin), an FDA approved drug for cancer treatment, is a topoisomerase I inhibitor with potent antineoplastic activity.

Ellagic acid (Elagostasine, Gallogen; Alizarine Yellow; Benzoaric acid; CCRIS-774; HSDB-7574; Lagistase), the dilactone of hexahydroxydiphenic acid, is a naturally occuring phenol and an antioxidant found in numerous fruits and vegetables.

Pirarubicin (THP; THPADM; THPDOX; 1609RB; THP-Adriamycin; THP-Doxorubicin; Pinorubicin; Theprubicine; Therarubicin) is an analog of anthracycline with potential antitumor activity.

Pixantrone dimaleate, the dimaleate salt of Pixantrone (formerly known as BBR 2778) and an aza-anthracenedione analog, is a weak topoisomerase II inhibitor and DNA intercalator with anticancer activity with little cardiotoxicity.

Amonafide (formerly NSC308847, AS1413; AS-1413; NSC-308847; Amonafide; Nafidimide; Benzisoquinolinedione; Quinamed; Xanafide), an imide derivative of naphthalic acid, is an inhibitor of topoisomerase II (Topo II) and also a DNA intercalator being investigated for the treatment of cancer.