Camptothecin (Campathecin)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $345 | Check With Us |
| 10g | $645 | Check With Us |
| 20g | $965 | Check With Us |
: Cat #: V1391 CAS #: 7689-03-4 Purity ≥ 98%
Description: Camptothecin (also known as Campathecin; CPT; NSC-100880), a naturally occurring quinoline alkaloid, is a potent and specific inhibitor of DNA enzyme topoisomerase I (Topo I) with potent antitumor activity.
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- Physicochemical and Storage Information
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- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 348.35 |
|---|---|
| Molecular Formula | C20H16N2O4 |
| CAS No. | 7689-03-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 3 mg/mL (8.6 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | 30% PEG400+0.5% Tween80+5% Propylene glycol: 30 mg/mL |
| Synonyms | NSC-100880; (S)-(+)-Camptothecin; Camptothecine; (S)-(+)-Camptothecin; NSC100880; NSC 100880; d-Camptothecin; 20(S)-Camptothecine; (+)-Camptothecin; Camptothecin; CPT. |
| Protocol | In Vivo | Camptothecin (2 mg/kg every other day) treats mice, has developed numerous pulmonary metastases. Treatment with both kinase inhibitor of nuclear factor-kappaB-1 (KINK-1) and Camptothecin led to a statistically significant reduction in the number of pulmonary metastases |
|---|---|---|
| Animal model | C57BL6 mice (injected with B16F10 melanoma cells) | |
| Dosages | 2 mg/kg | |
| Administration | every other day, after 19 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8707 mL | 14.3534 mL | 28.7068 mL | 57.4135 mL |
| 5mM | 0.5741 mL | 2.8707 mL | 5.7414 mL | 11.4827 mL |
| 10mM | 0.2871 mL | 1.4353 mL | 2.8707 mL | 5.7414 mL |
| 20mM | 0.1435 mL | 0.7177 mL | 1.4353 mL | 2.8707 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.