VU 0361737 (VU0361737; VU-0361737) is a novel, brain-penetrable and selective positive allosteric modulator (PAM) for mGlu4 receptor with important biological activity.

Riluzole (formerly PK26124, RP54274, RP-54274, PK-26124; Rilutek), an anticonvulsant of the Na+ channel blocker class, is a glutamate release inhibitor with neuroprotective, anticonvulsant, anxiolytic and anesthetic activities.

VU0357121 (VU-0357121, VU 0357121) is a positive allosteric modulator (PAM) of mGlu5 (metabotropic glutamate receptor 4) with antiparkinsonian-like effects.

Transcrocetin is a novel and potent apocarotenoid dicarboxylic acid.

Piracetam (BRN-1526393; UCB-6215; Cl-871; Breinox; Ciclofalina; Euvifor; Gabacet; Nootron) is a cyclized derivative of the neurotransmitter gamma-aminobutyric acid (GABA) that has been approved for use in the treatment of a wide range of cognitive disorders.

MPEP is a highly potent, selective, and non-competitive antagonist of mGlu5 receptor with anti-anxiolytic/antidepressant activity.

AP-5 (AP5) is a novel, selective and potent NMDA (N-methyl-D-aspartate) receptor antagonist with anticonvulsant activity.

VU 0364770 (VU-0364770, VU0364770) is a potent positive allosteric modulator (PAM) of mGlu4 (metabotropic glutamate receptor 4) with anti-parkinsonian-like activity.

NMDA (N-Methyl-D-aspartic acid; LC488A; LC488 A; LC488-A; LC 488A; LC-488A) is an aspartic acid analog with an N-methyl substituent and D-configuration and a glutamate-like excitatory chemical substance.

Dizocilpine (MK-801), is a novel, potent, selective and non-competitive NMDA ( N-Methyl-D-aspartate) receptor antagonist with Kd of 37.2 nM in rat brain membranes.