MPEP
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $1350 | Check With Us |
| 5g | $4050 | Check With Us |
| 10g | $6075 | Check With Us |
: Cat #: V1089 CAS #: 96206-92-7 Purity ≥ 98%
Description: MPEP is a highly potent, selective, and non-competitive antagonist of mGlu5 receptor with anti-anxiolytic/antidepressant activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 193.24 |
|---|---|
| Molecular Formula | C14H11N |
| CAS No. | 96206-92-7 |
| Storage | -20℃ for 3 years in powder formrrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 39 mg/mL (201.8 mM)rrr |
| Water: <1 mg/mLrrr | |
| Ethanol: 39 mg/mL (201.8 mM) | |
| Solubility In Vivo | 2% DMSO+30% PEG 300+5% Tween 80: 10 mg/mL |
| SMILES Code | Cc1cccc(n1)C#Cc2ccccc2 |
| Synonyms | 2-methyl-6-(phenylethynyl)-pyridine; MPEP; MPEP HCl; MPEP hydrochloride |
| Protocol | In Vitro | MPEP does not show agonist or antagonist activity at 100 mM on human mGlu2, -3, -4a, -7b, and -8a receptors nor at 10 μM on the human mGlu6 receptor |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 5.1749 mL | 25.8746 mL | 51.7491 mL | 103.4982 mL |
| 5mM | 1.0350 mL | 5.1749 mL | 10.3498 mL | 20.6996 mL |
| 10mM | 0.5175 mL | 2.5875 mL | 5.1749 mL | 10.3498 mL |
| 20mM | 0.2587 mL | 1.2937 mL | 2.5875 mL | 5.1749 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.