VU 0361737
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1150 | Check With Us |
| 1g | $1950 | Check With Us |
| 5g | $5850 | Check With Us |
: Cat #: V1092 CAS #: 1161205-04-4 Purity ≥ 98%
Description: VU 0361737 (VU0361737; VU-0361737) is a novel, brain-penetrable and selective positive allosteric modulator (PAM) for mGlu4 receptor with important biological activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 262.69 |
|---|---|
| Molecular Formula | C13H11ClN2O2 |
| CAS No. | 1161205-04-4 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 53 mg/mL (201.8 mM)rr |
| Water: <1 mg/mLrr | |
| Ethanol: <1 mg/mL | |
| SMILES Code | O=C(C1=NC=CC=C1)NC2=CC=C(Cl)C(OC)=C2 |
| Synonyms | VU 0361737, VU-0361737, VU0361737; ML 128; ML-128; ML128 |
| Protocol | In Vitro | VU0361737 displays weak activity at mGlu5 and mGlu8 receptors and inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors |
|---|---|---|
| In Vivo | VU0361737 exhibits terminal elimination half-lives (rat 1.9 h) due to high plasma clearance (894 mL/min/kg) following Intraperitoneal injection ( rat 10 mg/kg) | |
| Animal model | Male Sprague-Dawley rats (225-250 g) | |
| Dosages | 10 mg/kg (Pharmacokinetic Analysis) | |
| Administration | Intraperitoneal injection |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.8068 mL | 19.0338 mL | 38.0677 mL | 76.1354 mL |
| 5mM | 0.7614 mL | 3.8068 mL | 7.6135 mL | 15.2271 mL |
| 10mM | 0.3807 mL | 1.9034 mL | 3.8068 mL | 7.6135 mL |
| 20mM | 0.1903 mL | 0.9517 mL | 1.9034 mL | 3.8068 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.