Riluzole (RP-54274, PK 26124)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $450 | Check With Us |
| 10g | $700 | Check With Us |
| 20g | $1050 | Check With Us |
: Cat #: V1078 CAS #: 1744-22-5 Purity ≥ 98%
Description: Riluzole (formerly PK26124, RP54274, RP-54274, PK-26124; Rilutek), an anticonvulsant of the Na+ channel blocker class, is a glutamate release inhibitor with neuroprotective, anticonvulsant, anxiolytic and anesthetic activities.
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| Molecular Weight (MW) | 234.2 |
|---|---|
| Molecular Formula | C8H5F3N2OS |
| CAS No. | 1744-22-5 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 47 mg/mL (200.7 mM)rr |
| Water: <1 mg/mLrr | |
| Ethanol: 47 mg/mL (200.7 mM) | |
| SMILES Code | NC1=NC2=CC=C(OC(F)(F)F)C=C2S1 |
| Synonyms | PK 26124, RP 54274, PK26124, RP54274, RP-54274, PK-26124; Rilutek |
| Protocol | In Vitro | Riluzole is an anticonvulsant that belongs to the family of use-dependent Na-channel blockers that also inhibit GABA uptake, IC+50 is 43 μM. At 20 μM, Riluzole only slightly suppresses peak self-touching IPSC, but reliably lengthens IPSC. Riluzole was also found to cause intense, concentration-dependent, reversible enhancement of the 2 μM GABA response. At higher concentrations of Riluzole, especially 300 μM, GABA currents exhibit significant desensitization upon prolonged co-exposure to 2 μM GABA and Riluzole. Riluzole enhances the EC of GABA reactions50 Approximately 60 μM |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.2699 mL | 21.3493 mL | 42.6985 mL | 85.3971 mL |
| 5mM | 0.8540 mL | 4.2699 mL | 8.5397 mL | 17.0794 mL |
| 10mM | 0.4270 mL | 2.1349 mL | 4.2699 mL | 8.5397 mL |
| 20mM | 0.2135 mL | 1.0675 mL | 2.1349 mL | 4.2699 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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C1
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V1
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.