Dizocilpine (MK-801)

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$650	Check With Us
500mg	$980	Check With Us
1g	$1470	Check With Us

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Cat #: V5684 CAS #: 77086-21-6 Purity ≥ 98%

Description: Dizocilpine (MK-801), is a novel, potent, selective and non-competitive NMDA ( N-Methyl-D-aspartate) receptor antagonist with Kd of 37.2 nM in rat brain membranes.

References: Dizocilpine (MK 801) (1 mg/kg) treatment before each METH injection reduces the extent of DA depletion by 55% in striatal of mice. Dizocilpine (MK 801) (1 mg/kg) also attenuates the effects of METH on microglial activation in striatal of mice

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Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	221.303
Molecular Formula	C16H15N
CAS No.	77086-21-6
SMILES Code	C[C@]1(N2)C3=CC=CC=C3CC2C4=CC=CC=C14
Synonyms	Dizocilpine; MK801; MK 801; MK-801; MK 801 Maleate; Related CAS#: 77086-21-6 (free base);

Protocol	In Vitro	Dizocilpine (MK-801; <500 μM) inhibits activation of microglia induced by LPS with increased Cox-2 protein expression in BV-2 cells. Dizocilpine (<500 μM) reduces microglial TNF-α output with an EC50 of 400 μM in BV-2 cells
Protocol	In Vivo	Dizocilpine (MK 801) (1 mg/kg) treatment before each METH injection reduces the extent of DA depletion by 55% in striatal of mice. Dizocilpine (MK 801) (1 mg/kg) also attenuates the effects of METH on microglial activation in striatal of mice

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	4.5187 mL	22.5935 mL	45.1869 mL	90.3738 mL
5mM	0.9037 mL	4.5187 mL	9.0374 mL	18.0748 mL
10mM	0.4519 mL	2.2593 mL	4.5187 mL	9.0374 mL
20mM	0.2259 mL	1.1297 mL	2.2593 mL	4.5187 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.