CAY10404 is novel, and highly selective inhibitor of COX-2 which has been reported to date, with a selectivity index (SI; SI = IC50 COX-1/IC50 COX-2) of >500,000.

Diflunisal (also known as MK-647; trade name Dolobid) is a novel and potent salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, it is used alone as an analgesic and in rheumatoid arthritis patients.

ATB-346, a structural analog of naproxen (one of the NSAIDs-Nonsteroidal anti-inflammatory drugs), is anti-inflammatory agent.

Parecoxib sodium ( SC-69124A; Dynastat) is a novel and potent cyclooxygenase-2/COX-2 inhibitor with the potential for treating postoperative pain in adults.

Chebulagic acid is a naturally occurring COX-LOX dual inhibitor isolated from the Terminalia chebula Retz.

Parecoxib (SC69124A; Dynastat) is a selective cyclooxygenase-2 (COX-2) inhibitor with the potential for treating postoperative pain in adults.

Diclofenac potassium (Voltarol; Voltaren), the potassium salt of diclofenac, is a nonsteroidal anti-inflammatory drug (NSAID) that is able to reduce inflammation and to be used as an analgesic reducing pain in certain conditions.

Byakangelicol is a novel and potent anti-inflammatory drug.

Esflurbiprofen (BTS-24332; TT 063; BTS24332; TT063; SFPP; BTS 24332; TT-063; Trade name: Loqoa), the S-enantiomrer or S-isomer of Flurbiprofen, is a potent cyclooxygenase (COX) inhibitor and a nonsteroidal anti-inflammatory drugs (NSAIDs) with antipyretic and analgesic activity.

Diclofenac (formerly GP-45840; Voltarol; Voltaren) is a potent nonsteroidal anti-inflammatory drug (NSAID), acting as a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used to relieve pain and reduce swelling in flammation.