Chebulagic acid
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1950 | To Be Confirmed |
| 200mg | $2925 | To Be Confirmed |
| 500mg | $4935 | To Be Confirmed |
: Cat #: V31341 CAS #: 23094-71-5 Purity ≥ 99%
Description: Chebulagic acid is a naturally occurring COX-LOX dual inhibitor isolated from the Terminalia chebula Retz.
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- Protocol
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| Molecular Weight (MW) | 954.66 |
|---|---|
| Molecular Formula | C41H30O27 |
| CAS No. | 23094-71-5 |
| SMILES Code | O[C@H]1[C@H]2[C@@H](C(O[C@@H]3[C@H]4COC(c5c(c6c(C(O[C@@H]3[C@H]([C@@H](O4)OC(c7cc(O)c(O)c(O)c7)=O)OC(c8c2c(OC1=O)c(O)c(O)c8)=O)=O)cc(O)c(O)c6O)c(O)c(O)c(O)c5)=O)=O)CC(O)=O |
| Synonyms | Chebulagic acid; NSC 342674; NSC 342674; NSC 342674 |
| Protocol | In Vitro | Chebulagic acid can enhance the autophagy. Chebulagic acid exert anti-inflammatory and anti-infective effects. Chebulagic acid also shows a protective effect against 1-methyl-4-phenylpyridinium (MPP+)-induce cytotoxicity which mimics the pathological symptom of Parkinson's disease. Chebulagic acid inhibits the LPS-induced upregulation of TNF-α and IL-1β in a dose- and time-dependent manner. Furthermore, LPS-activated MAPK signaling is inhibited by Chebulagic acid treatment in the EA.hy926 cells. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.0475 mL | 5.2375 mL | 10.4749 mL | 20.9499 mL |
| 5mM | 0.2095 mL | 1.0475 mL | 2.0950 mL | 4.1900 mL |
| 10mM | 0.1047 mL | 0.5237 mL | 1.0475 mL | 2.0950 mL |
| 20mM | 0.0524 mL | 0.2619 mL | 0.5237 mL | 1.0475 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.