Diclofenac potassium
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 25g | $450 | Check With Us |
| 50g | $750 | Check With Us |
| 100g | $1125 | Check With Us |
: Cat #: V38709 CAS #: 15307-81-0 Purity ≥ 99%
Description: Diclofenac potassium (Voltarol; Voltaren), the potassium salt of diclofenac, is a nonsteroidal anti-inflammatory drug (NSAID) that is able to reduce inflammation and to be used as an analgesic reducing pain in certain conditions.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 334.24 |
|---|---|
| Molecular Formula | C14H10Cl2KNO2 |
| CAS No. | 15307-81-0 |
| SMILES Code | O=C([O-])CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl.[K+] |
| Synonyms | CGP-45840B; CGP45840B; CGP 45840B; Diclofenac potassium; |
| Protocol | In Vitro | Diclofenac effectively blocks COX-1 mediated prostanoid production from U937 cell microsomes, with an IC50 of 7±3 nM. |
|---|---|---|
| In Vivo | Diclofenac (10 mg/kg; administered via oral route just prior to induction of inflammation) shows in vivo anti-inflammatory activity in Wistar rats. Diclofenac (3 mg/kg, b.i.d., for 5 days) significantly increases faecal 51Cr excretion in rats, and such effect is also observed in squirrel monkeys after administrated of 1 mg/kg twice daily for 4 days. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9919 mL | 14.9593 mL | 29.9186 mL | 59.8372 mL |
| 5mM | 0.5984 mL | 2.9919 mL | 5.9837 mL | 11.9674 mL |
| 10mM | 0.2992 mL | 1.4959 mL | 2.9919 mL | 5.9837 mL |
| 20mM | 0.1496 mL | 0.7480 mL | 1.4959 mL | 2.9919 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.