Indotecan (LMP400; NSC724998) is a novel, potent and selective topoisomerase I inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively.

Aldoxorubicin HCl (formerly MC-DOXHZN; INNO-206; Doxo-EMCH; INNO206), the hydrochloride salt of Aldoxorubicin, is a albumin-binding prodrug of doxorubicin (an anthracycline antibiotic anticancer drug, and a DNA topoisomerase II inhibitor).

Pirarubicin hydrochloride (THP), an analogue of anthracycline, is an anti-neoplastic doxorubicin which acts as a topoisomerase II inhibitor, and is used for treatment of various cancers, in particular, solid tumors.

Aclarubicin (Aclacinon; Aclacin; Aclaplastin; Aclacinomycine; Jaclacin. ACM; Aclacinomycin A) is a natually occuring oligosaccharide and anthracycline anticancer antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin is an inhibitor of topoisomerases I and II, acting by intercalating into DNA and interacting with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein […]

Irinotecan hydrochloride (also known as CPT-11; (+)-Irinotecan) is a potent topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.

Epirubicin HCl (formerly 4′-epidoxorubicin; epiADR; epidoxorubicin; IMI 28; IMI-28; Ellence; Pharmorubicin PFS), the hydrochloride salt of the 4′-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin, is a new anthracycline analog and a semisynthetic L-arabino derivative of doxorubicin approved as an anticancer medication.

Norfloxacin (AM-715, MK 0366; MK0366; AM715, MK-366, AM 715, MK366, MK 366, Noroxin, Chibroxin) is a broad-spectrum and synthetic chemotherapeutic antibiotic approved for the treatment of UTIs-urinary tract infections.

Exatecan mesylate (DX-8951) is the methylate of Exatecan, which is a semisynthetic analog of camptothecin with improved water solubility.

Novobiocin Sodium (formerly known as U6591, U-6591, Cathomycin, Inabiocin, Albadry, Streptonivicin, Albamycin) is a novel and potent antibiotic of the aminocoumarin class isolated from Streptomyces niveus and used for bacterial infections.

Irinotecan HCl trihydrate (formerly CPT-11; CPT 11; Irinophore C; Irinotecan lactone; Irinotecanum ), the hydrochloride salt and trihydrated form of irinotecan which is an antitumor drug and a soluble prodrug of SN-38, is a semisynthetic derivative of camptothecin approved for cancer treatment.