Norfloxacin (MK-0366)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50g | $400 | Check With Us |
| 100g | $650 | Check With Us |
| 200g | $975 | Check With Us |
: Cat #: V1409 CAS #: 70458-96-7 Purity ≥ 98%
Description: Norfloxacin (AM-715, MK 0366; MK0366; AM715, MK-366, AM 715, MK366, MK 366, Noroxin, Chibroxin) is a broad-spectrum and synthetic chemotherapeutic antibiotic approved for the treatment of UTIs-urinary tract infections.
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| Molecular Weight (MW) | 319.33 |
|---|---|
| Molecular Formula | C16H18FN3O3 |
| CAS No. | 70458-96-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 3 mg/mL (9.4 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Synonyms | MK-0366; Norfloxacin, AM-715, MK 0366; MK0366; AM715, MK-366, AM 715, MK366, MK 366, Noroxin, Chibroxin |
| Protocol | In Vitro | Norfloxacin (MK-0366) is a synthetic chemotherapeutic antibacterial agent occasionally used to treat common as well as complicated urinary tract infections. Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial DNA, thereby inhibiting cell division.There are currently three approved uses in the adult population (one of which is restricted) and the other ineffective due to bacterial resistance. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.1316 mL | 15.6578 mL | 31.3156 mL | 62.6311 mL |
| 5mM | 0.6263 mL | 3.1316 mL | 6.2631 mL | 12.5262 mL |
| 10mM | 0.3132 mL | 1.5658 mL | 3.1316 mL | 6.2631 mL |
| 20mM | 0.1566 mL | 0.7829 mL | 1.5658 mL | 3.1316 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.