Exatecan mesylate (DX8951)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1750 | Check With Us |
| 250mg | $2650 | Check With Us |
| 500mg | $3975 | Check With Us |
: Cat #: V20873 CAS #: 169869-90-3 Purity ≥ 98%
Description: Exatecan mesylate (DX-8951) is the methylate of Exatecan, which is a semisynthetic analog of camptothecin with improved water solubility.
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| Molecular Weight (MW) | 531.55 |
|---|---|
| Molecular Formula | C25H26FN3O7S |
| CAS No. | 169869-90-3 |
| Protocol | In Vitro | Exatecan mesylate is a potent topoisomerase I inhibitor, with an IC50 of 0.975 μg/mL. Exatecan mesylate (DX-8951f) significantly inhibits the proliferation of several cancer cell lines, with mean GI50s of 2.02 ng/mL, 2.92 ng/mL, 1.53 ng/mL, and 0.877 ng/mL for breast cancer cells, colon cancer cells, stomach cancer cells and lung cancer cells, respectively |
|---|---|---|
| In Vivo | Exatecan mesylate (DX-8951f, 3.325-50 mg/kg, i.v.) exhibits antitumor activities in the mice model bearing tumor cells, without toxic death |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8813 mL | 9.4065 mL | 18.8129 mL | 37.6258 mL |
| 5mM | 0.3763 mL | 1.8813 mL | 3.7626 mL | 7.5252 mL |
| 10mM | 0.1881 mL | 0.9406 mL | 1.8813 mL | 3.7626 mL |
| 20mM | 0.0941 mL | 0.4703 mL | 0.9406 mL | 1.8813 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.