VPS34 inhibitor 1 (also known as Vps34-IN1, Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34 the potential to serve as a chemical tool to modulate autophagy in Vivo.

A66 is a novel, potent, reversible, ATP-competitive and highly selective p110α inhibitor with potential anticancer activity.

TGX-221 is a novel, potent, selective, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit with potential anticancer activity.

Deguelin [(-)-Deguelin, (-)-cis-Deguelin], a naturally occurring rotenoid isolated from plants in the Mundulea sericea family, is an Akt inhibitor with anti-tumor effect on several cancers; it acts by decreasing levels of phosphorylated Akt.

GNE-477 is a novel, potent and efficacious dual inhibitor of PI3K (IC50=4 nM)/mTOR(Ki=21 nM).

PF-04979064 is a novel, potent and selective PI3K/mTOR dual kinase inhibitor with Kis of 0.13 nM and 1.42 nM for PI3Kα and mTOR, respectively.

NSC781406 is a novel and highly potent dual inhibitor of PI3K and mTOR with an IC50 of 2 nM for PI3Kα.

Fimepinostat (also known as CUDC-907) is a potent, orally bioavailable, and small molecule dual inhibitor of PI3K and HDAC (PI3Kα and HDAC1/2/3/10) with potential anticancer activity.

PI-103 Hydrochloride (PI 103; PI103), the hydrochloride salt of PI-103, is a multi-targeted PI3K and mTOR inhibitor with potential antineoplastic activity.

CAY10505, the dehydroxylated form of AS-252424, is a novel, potent and selective inhibitor of PI3Kγ (phosphoinositide 3-kinase) with a potential to improve hypertension-associated vascular endothelial dysfunction.