NSC-781406
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1340 | To Be Confirmed |
| 500mg | $1950 | To Be Confirmed |
| 1g | $2925 | To Be Confirmed |
: Cat #: V5023 CAS #: 1676893-24-5 Purity ≥ 98%
Description: NSC781406 is a novel and highly potent dual inhibitor of PI3K and mTOR with an IC50 of 2 nM for PI3Kα.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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| Molecular Weight (MW) | 627.68 |
|---|---|
| Molecular Formula | C29H27F2N5O5S2 |
| CAS No. | 1676893-24-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=S(C1=CC=C(F)C=C1F)(NC2=CC(C3=CC=C4N=CC=C(C#CCN5CCN(S(=O)(C)=O)CC5)C4=C3)=CN=C2OC)=O |
| Synonyms | NSC-781406; NSC 781406; NSC781406 |
| Protocol | In Vitro | NSC781406 demonstrates potent PI3K inhibition (PI3Kα IC50=2.0 nM) that translates into BEL-7404 cells proliferation inhibition (IC50=20 nM). NSC781406 displays reasonable liver microsome stability. NSC781406 demonstrates cytotoxic activities against leukemia, non-small cell, lung cancer, colon cancer, central nervous system cancer, melanoma, ovarian cancer, renal cancer, prostate cancer, and breast cancer. It is potent against 60 cancer cell lines with a mean GI50 value of 65 nM, and with a GI50 value less than 10 nM against four cancer cell lines. |
|---|---|---|
| In Vivo | In the xenograft models, treatment with 30 mg/kg of NSC781406 results in statistically significant antitumor activity, with a mean reduction in relative tumor volume ratio of 52%. Sorafenib displays an inhibition ratio of 44% at 50 mg/kg. NSC781406 is well tolerated at 30 mg/kg, with no observed mortality or significant reduction of body weight. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.5932 mL | 7.9658 mL | 15.9317 mL | 31.8634 mL |
| 5mM | 0.3186 mL | 1.5932 mL | 3.1863 mL | 6.3727 mL |
| 10mM | 0.1593 mL | 0.7966 mL | 1.5932 mL | 3.1863 mL |
| 20mM | 0.0797 mL | 0.3983 mL | 0.7966 mL | 1.5932 mL |
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
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Method for preparing in vivo formulation:
Take
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DMSO master liquid, next add
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PEG300, mix and clarify, next add
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Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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