Homosalate is an organic chemical compound used in sunscreens and cosmetics as a UV filter to absorb ultraviolet radiation in the UVB range, thus protecting the skin from sun damage.
ZSTK474 is a novel, potent and ATP-competitive pan-PI3K inhibitor (class I) with potential anticancer activity.
PI3K inhibitor 1 is a novel and potent PI3K inhibitor.
PIK-75 HCl, the hydrochloride salt of PIK-75, is a novel, potent, selective and imidazopyridine-based p110α inhibitor with potential anticancer activity and with IC50 of 5.8 nM, which is 200-fold more potent than p110β.
PIK-90 is a novel and potent PI3Kα/γ/δ inhibitor with potential anticancer activity.
TG100-115 is a novel, potent and selective PI3Kγ/δ inhibitor with potential cardioprotecting effects.
PIK-93, a phenylthiazole analog, is a novel, potent, and selective PI4K (PI4KIIIβ) inhibitor with antiviral effects (antienterovirus activity).
Bimiralisib (also known as PQR-309; PI3K-IN-2) is an orally bioavailable, brain-penetrant, and balanced pan-inhibitor of PI3K/mTOR (phosphoinositide-3-kinase/mammalian target of rapamycin) with IC50s of 33 nM, 451 nM, 661 nM, 708 nM and 89 nM for PI3Kα, PI3Kδ, PI3Kβ, PI3Kγ and mTOR, respectively.
Sonolisib (also known as PX-866), a wortmannin analog, is a novel, an oral, irreversible, and pan-isoform small-molecule inhibitor of phosphoinositide 3-kinase/PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)) with with potential antineoplastic activity. antitumor activity.
CH5132799 is a novel and potent class I PI3K (phosphoinositide 3-kinase) inhibitor with potential anticancer activity.