A66

This product is for research use only, not for human use. We do not sell to patients.

A66
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$899Check With Us
500mg$1230Check With Us
1g$1845Check With Us

Cat #: V0118 CAS #: 1166227-08-2 Purity ≥ 98%

Description: A66 is a novel, potent, reversible, ATP-competitive and highly selective p110α inhibitor with potential anticancer activity.

References: Jamieson S, et al. A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochem J, 2011, 438(1), 53-62.

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Molecular Weight (MW)393.53
Molecular FormulaC17H23N5O2S2
CAS No.1166227-08-2
SMILES CodeO=C(N1[C@H](C(N)=O)CCC1)NC2=NC(C)=C(C3=CSC(C(C)(C)C)=N3)S2
SynonymsA66; A-66; A 66
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.5411 mL12.7055 mL25.4110 mL50.8220 mL
5mM0.5082 mL2.5411 mL5.0822 mL10.1644 mL
10mM0.2541 mL1.2706 mL2.5411 mL5.0822 mL
20mM0.1271 mL0.6353 mL1.2706 mL2.5411 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.