SBI-477 is a novel and potent small molecule chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain–containing 4 (ARRDC4). SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes. It has the potential […]

DAMGO is a selective μ-opioid receptor (μ-OPR) agonist with Kd of 3.46 nM.

6-O-Methyl Guanosine is a modified nucleoside. 6-O-Methyl Guanosine (6-methylguanosine) inhibits colony formation in xeroderma pigmentosum cell lines.

Arctigenin ((-)-Arctigenin) is a bioactive lignan that can be used as an antitumor agent. Arctigenin has potent antioxidant, anti~inflammatory and antiviral (influenza A virus) activities. Arctigenin may be utilized in study/research of metabolic disorders and central nervous system dysfunction.

Ecastolol is a beta adrenergic receptor blocker (antagonist) that has anti-angina effects.

6”’-Feruloylspinosin is a natural flavonoid extracted from Ziziphus jujuba seeds. In rat hippocampal neurons, 6”’-Feruloylspinosin can penetrate the BBB (blood-brain barrier) and enhance the mRNA expression of GABAAα1, GABAAα5, and GABABR1.

Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves.With IC50s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug-resistant subline CEM/ADR5000, respectively, isoscopoletin exhibits significant inhibition against cell proliferation[1]. There is inhibitory activity of isoscopoletin (6-hydroxy-7-methoxycoumarin) against HBV replication .

JTT 551 is a selective protein tyrosine phosphatase 1B (PTP1B) inhibitor (antagonist) with Ki of 0.22 μM. It also has an effect on T cell protein tyrosine phosphatase (TCPTP) with Ki of 9.3 μM. It is available Research on type 2 diabetes.

2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and specific 5-HT3 receptor agonist (activator). 2-Methyl-5-HT displays antidepressant-like effects.

Diclofenac diethylamine is a potent nonsteroidal anti-inflammatory drug (NSAID), acting as a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used to relieve pain and reduce swelling in flammation. Diclofenac inhibits Wnt/beta-catenin signaling without altering the level of beta-catenin protein and reduces the expression […]