SBI-477 | CAS 781628-99-7

SBI-477

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
1mg	$170	To Be Confirmed
5mg	$430	To Be Confirmed
10mg	$690	To Be Confirmed

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Cat #: V29334 CAS #: 781628-99-7 Purity ≥ 99%

Description: SBI-477 is a novel and potent small molecule chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain–containing 4 (ARRDC4). SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes. It has the potential to be used as a therapeutic agebt for insulin resistance and lipotoxicity.

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Molecular Weight (MW)	483.5368
Molecular Formula	C24H25N3O6S
CAS No.	781628-99-7
Storage	Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Synonyms	SBI-477SBI 477SBI477

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.0681 mL	10.3405 mL	20.6809 mL	41.3619 mL
5mM	0.4136 mL	2.0681 mL	4.1362 mL	8.2724 mL
10mM	0.2068 mL	1.0340 mL	2.0681 mL	4.1362 mL
20mM	0.1034 mL	0.5170 mL	1.0340 mL	2.0681 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.