BioE-1115 (BioE 1115) is a novel, potent and highly selective PAS kinase (PASK) inhibitor with an IC50 of ~4 nM, it is also a potent casein kinase 2α inhibitor with an IC50 of ~10 μM. It is a dual inhibitor of PAS kinase (PASK) and casein kinase 2α (CK2α).

BIIE0246 (BIIE-0246) is a newly synthesized, potent and highly selective non-peptide neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 of 15 nM. It was able to compete with high affinity (8 to 15 nM) for specific [(125)I]PYY(3 – 36) binding sites in HEK293 cells transfected with the rat Y(2) receptor cDNA, and in rat […]

Flavoxate sulfate (Rec-7-0040; DW61) is a potent anticholinergic (AChR) agent that binds and inhibits muscarinic receptors, thereby suppressing the micturition reflex and increases urinary bladder capacity by modifying the micturition center in the brain stem. As an anticholinergic, Flavoxate has the potential to be used in various urinary syndromes and as an antispasmodic. Flavoxate (3 […]

AZD9977 is a novel, selective mineralocorticoid receptor modulator.

A134974 is a novel, potent and selective adenosine kinase (AK) inhibitor with IC50 of 60 pM. Systemic A-134974 (i.p.) dose dependently reduced hyperalgesia (ED(50) = 1 micromol/kg) and at higher doses, reduced locomotor activity (ED(50) = 16 micromol/kg). Administration of A-134974 intrathecally (i.t.) was more potent (ED(50) = 6 nmol) at producing antihyperalgesia than delivering […]

AZD7687 is a novel, potent, selective, reversible and pyrazinecarboxamide-based inhibitor of diacylglycerol acyltransferase 1 (DGAT1) with an IC50 value of 80 nM for hDGAT1. AZD7687 attenuates postprandial triacylglyceride excursion. AZD7687 markedly reduced postprandial TAG excursion with a steep concentration-effect relationship. Incremental TAG AUC (area under the serum concentration vs. time curve) following SMM 60% was […]

LB-100 (LB100) is a water soluble small-molecular protein phosphatase 2A (PP2A) inhibitor with anticancer activity. It inhibits PP2A with IC50 of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells. By using CCK-8 assays, LB-100 showed dose-dependent inhibition of cell growth in both cell lines. The IC50 of LB-100 was 0.85 μM and 3.87 […]

Sudoterb (formerly also known as LL3858; LL-3858) is a novel and potent drug candidate with the potential for treating Tuberculosis (TB). TB drug research and development efforts have resurged in the past 10 years to meet urgent medical needs, but enormous challenges remain. These urgent needs are largely driven by the current long and arduous […]

CY5.5 carboxylic acid (Cyanine5.5 carboxylic acid) is a novel and potent Far-red emitting fluorescent dye with Ex/Em wavelength 673nm/707nm. CY5.5 carboxylic acid can be considered non-reactive for most applications and used as a control or reference sample, and for instrument calibration.

FH1 (also known as NSC 12407, BRD-K4477) can enhance the functions of cultured hepatocytes by promoting differentiation of iPS-derived hepatocytes. FH1 belongs to the function-only hits which are screened out by their ability to permit renewable sourcing of functional human hepatocytes. Besides that, FH1 can promote differentiation of iPS-derived hepatocytes towards a more mature phenotype. […]